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Designed to mimic the body’s own hyaluronic acid (HA), Evolysse provides exceptionally natural-looking results by smoothing wrinkles, restoring volume, and sculpting the face with unparalleled integration and precision. Targeting smile lines, volume loss, or early signs of aging, Evolysse offers a refined, long-lasting solution with minimal swelling and virtually no downtime.


Evolysse is a new line of hyaluronic acid (HA)-based fillers developed using Cold-X™, a patented cold-temperature manufacturing process that protects the natural structure of HA. While most fillers are produced using high heat (which can damage HA bonds), Evolysse is processed at near-freezing temperatures. The result? A longer-lasting dermal with a more elastic formulation that integrates smoothly with facial tissues.
Unlike traditional fillers that may feel firm or look overly structured, Evolysse delivers a softer, more flexible result, perfect for areas where expression and subtlety matter most.
Evolysse comes in two FDA-approved formulations:
Both formulas are approved to treat nasolabial folds, with other off-label uses determined by your provider based on your anatomy and goals.


The Evolysse treatment is performed in-office and typically takes 30 to 45 minutes.
After cleansing the skin and mapping injection points, your provider may apply a topical anesthetic to ensure comfort. Using precise techniques and microcannulas or fine needles, the filler is then placed beneath the skin to lift, smooth, or contour the area. Thanks to Cold-X™ technology, most patients report very little discomfort or swelling, and the filler settles quickly into the tissue for an almost imperceptible feel.
Thanks to its Cold-X™ molecular integrity and soft-tissue integration, Evolysse can be used in a wide variety of facial zones.
Common treatment areas include:
Because it moves naturally with facial expressions, Evolysse is ideal for patients who want soft, subtle improvements without sacrificing flexibility or expression.

Evolysse offers several unique advantages over traditional dermal fillers.Cold-X™ Technology preserves the HA’s natural shape, allowing it to behave more like your own tissue. This means better integration, longer wear, and a softer feel.
Patients also experience less swelling and a faster recovery due to the purity and consistency of the filler, making Evolysse an excellent option for anyone seeking noticeable results without post-treatment downtime.
Other benefits include:
Sustained correction for up to 12 months in many patients
You may be an ideal candidate for Evolysse if you:
During your consultation, our expert providers will evaluate your facial structure and recommend either Evolysse Smooth, Evolysse Form, or a combination approach, depending on your unique facial anatomy and aesthetic goals.


There’s very little recovery needed after the Evolysse treatment. Some patients experience mild redness or tenderness, but swelling is typically minimal due to the clean manufacturing process. Most people return to routine activities the same day.
You’ll see improvement immediately, and full results will become more refined over the first few days. Evolysse has shown results lasting up to 12 months, depending on the area treated and your body’s metabolism. For long-term maintenance, follow-up treatments may be recommended annually or biannually.

At Ocean Drive Dermatology, we go beyond basic injections. Our board-certified team understands that filler work is both a science and an art, and your face deserves the highest level of both.
We specialize in advanced injection techniques that honor your natural features while delivering meaningful results. Whether you’re looking for subtle smoothing or structural sculpting, we’ll tailor your Evolysse experience to your unique aesthetic goals in our serene, beachside Vero Beach setting.

Evolysse fillers are made using Cold-X™ technology, which preserves the natural structure of hyaluronic acid during manufacturing. This results in a filler that’s smoother, more elastic, and better integrated with facial tissues than many traditional fillers. Patients often report more natural movement and less swelling with Evolysse.
Yes, Evolysse Smooth and Evolysse Form are both FDA-approved for the correction of nasolabial folds (smile lines). These approvals ensure that the products have been rigorously tested for safety, effectiveness, and long-term performance in clinical settings.
Evolysse fillers typically provide visible results for up to 12 months, though longevity can vary based on the individual’s metabolism, treatment area, and lifestyle. Some areas of the face that experience less movement may retain results even longer.
Most patients experience little to no downtime after Evolysse treatments. Thanks to the Cold-X™ manufacturing process, swelling and bruising are minimal compared to other HA fillers. You can typically return to regular activities the same day or the day after your treatment.
There’s med spas, and then there’s Ocean Drive Med Spa. Led by Dr. Alan Durkin, Ocean Drive Med Spa is well known among industry professionals as a center for innovation.
Pioneering new technologies and treatments, Ocean Drive Med Spa constantly researches new technologies to ensure the best results for its patients. Ocean Drive Med Spa also features one of the largest laser and energy centers in the nation, offering patients treatments with the latest state-of-the-art tools to create incredible aesthetic experiences. Begin yours today with an appointment at Ocean Drive Med Spa.